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A novel two‐component self‐assembling chimeric peptide is designed where two orthogonal protein folding motifs are linked side by side with precisely defined position relative to one another. The self‐assembly is driven by a combination of symmetry controlled molecular packing, intermolecular interactions, and geometric constraint to limit the assembly into compact dodecameric protein nanoparticles...
A biofabrication strategy for creating planar multiscale protein, hydrogel, and cellular patterns, and simultaneously generating microscale topographical features is developed that laterally confines the patterned cells and direct their growth in cell permissive hydrogels.
Biomedical applications of non‐spherical nanoparticles such as photothermal therapy and molecular imaging require their efficient intracellular delivery, yet reported details on their interactions with the cell remain inconsistent. Here, the effects of nanoparticle geometry and receptor targeting on the cellular uptake and intracellular trafficking are systematically explored by using C166 (mouse...
Functional and phenotypic analyses of peripheral white blood cells provide useful clinical information. However, separation of white blood cells from peripheral blood requires a time‐consuming, inconvenient process and thus analyses of separated white blood cells are limited in clinical settings. To overcome this limitation, a microfluidic separation platform is developed to enable deterministic migration...
An efficient particle‐based DNA circuit system for a new colorimetric miRNA assay is designed and devised based on a catalytic disassembly strategy through a target miRNA‐triggered DNA circuit mechanism. The new particle‐based DNA circuit system shows a rapid color change as well as significant improvement of sensitivity without need for other enzymes or instruments.
The mode volume and Purcell factor are two important parameters to assess the performance of optical nanocavities. Achieving small mode volumes and high Purcell factors for nanocavity structures while simplifying their fabrication has been a major task to realize high‐performance and large‐scale photonic devices and systems. Different optical resonators based on nanoparticle‐on‐mirror (NPoM) structures...
A design strategy for fully flexible electrode arrays with out‐of‐plane through polymer vias (TPVs) for monolithic 3D integration of sensor readout circuitry is presented. The TPVs are formed using copper embedded in thin polyimide structure for support. The copper interconnects offer a stable impedance frequency response from DC to 100 kHz (Z ≈ 20 Ω, θ ≈ 0°).
Intracellular delivery of proteins is a promising strategy of intervention in disease, which relies heavily on the development of efficient delivery platforms due to the cell membrane impermeability of native proteins, particularly for negatively charged large proteins. This work reports a vesicle supra‐assembly approach to synthesize novel amine‐functionalized hollow dendritic mesoporous silica nanospheres...
Thermoelectric NaCo2O4/TiO2 coaxial nanofibers are prepared and distributed in the perovskite solar cells. Under illumination, p‐type NaCo2O4 can convert unwanted heat to thermal voltage, and thus promote the electron extraction and transport with the action of electrostatic force. These advantages collectively contribute to an overall power conversion efficiency improvement of ≈20% (15.14% vs 12...
The well‐matched electrochemical parameters of positive and negative electrodes, such as specific capacitance, rate performance, and cycling stability, are important for obtaining high‐performance asymmetric supercapacitors. Herein, a facile and cost‐effective strategy is demonstrated for the fabrication of 3D densely stacked graphene (DSG) and graphene‐MnO2 (G‐MnO2) architectures as the electrode...
Plasmonic organic solar cells with an efficiency of 10.5% are achieved by simultaneous plasmon‐optical and plasmon‐electrical effects from gold nanostars, as presented by W. C. H. Choy and co‐workers on page 5200. Due to the excited plasmonic asymmetric modes, their optical effects induce a broadband absorption enhancement. Meanwhile, their electrical effects of offering better balanced carrier transport...
A polydimethylsiloxane microchannel featuring sidewall sharp‐edge structures and bare channels, and a piezoelement transducer is attached to a thin glass slide. When an external acoustic field is applied to the microchannel, the oscillation of the sharp‐edge structures and the thin glass slide generate acoustic streaming flows which in turn rotate single cells and C. elegans in‐plane and out‐of‐plane...
The plasmon‐optical effects have been utilized to optically enhance active layer absorption in organic solar cells (OSCs). The exploited plasmonic resonances of metal nanomaterials are typically from the fundamental dipole/high‐order modes with narrow spectral widths for regional OSC absorption improvement. The conventional broadband absorption enhancement (using plasmonic effects) needs linear‐superposition...
On page 5141, A. M. Hussain and M. M. Hussain report a process for fabricating electronics and sensor arrays on the opposite sides of the same flexible polymer, which can lead to the development of high resolution brain machine interfaces (BMI). The fabrication is done monolithically in a single process‐flow, following which the polymer is released to obtain a flexible device with sensors on one side...
Graphene aerogels (GAs) anchoring hierarchical, mulberry‐like ZnO particles are fabricated in situ using a one‐step solvothermal reaction. The resulting composites can function as anodes in lithium ion batteries, where they exhibit a high capacity and cyclic stability. The reversible capacities obtained are 365, 320, and 230 mA h g−1 at current densities of 1, 2, and 10 A g−1. Their high reversible...
Taking advantage of the highly permeable vasculature and lack of lymphatic drainage in solid tumors (EPR effect), nanosized drug delivery systems or nanomedicines have been extensively explored for tumor‐targeted drug delivery. However, in most clinical cases tumors such as the early stage tumors and post‐surgery microscopic residual tumors have not yet developed such pathological EPR features, i...
On page 5159, E.‐C. Shin, S. Choi, and co‐workers describe a microfluidic platform to steer the target cells into designated positions and thus enable high‐throughput separation. The platform provides an easy‐to‐use and fast‐to‐perform solution for rapid preparation of enriched white blood cells, improving the diagnostic use of the cells.
On page 5120, T. J. Huang and co‐workers attach a polydimethylsiloxane microchannel featuring sidewall sharp‐edge structures and bare channels, and a piezoelement transducer, to a thin glass slide. Oscillation of polydimethylsiloxane sidewall sharp‐edge structures generates acoustic streaming flows, which in turn rotate single cells and C. elegans inside a microchannel.
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